Aplastic Anaemia

Aplastic Anaemia.

Aplastic anaemia: a review.

Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppress...

Aplastic Anaemia in Children.

A anaemia is a life threatening blood disorder that affects a large number of children each year in India. Exposure to toxic agents like benzene, radiation and viruses like hepatitis A have been implicated in its aetiology. The incidence in developing countries is far higher compared to developed countries. Investigating a child with pancytopenia is more complex than that of an adult as numerou...

Successful pregnancy following aplastic anaemia.

Pregnancy following idiopathic aplastic anaemia is rare and is difficult to manage because of life-threatening episodes of bleeding and infections. Only a handful of cases has been reported in the literature. The pregnancies were unsuccessful in the majority. The present report describes a patient with moderately severe idiopathic aplastic anaemia who was managed with intensive haematological s...

Immunosuppressive Therapy for Aplastic Anaemia.

Immunosuppressive therapy is the standard of care in aplastic anaemia in younger patients who do not have a matched sibling donor, and also in adults and older patients. Hence, a large population of patients with aplastic anaemia undergo this treatment. In patients who have responded to the first course of ATG, and have had a relapse, a second course of ATG can be administered with reasonable r...