منابع مشابه
Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms
Pore-forming proteins play critical roles in pathogenic attack and immunological defence. The membrane attack complex/perforin (MACPF) group of homologues represents, with cholesterol-dependent cytolysins, the largest family of such proteins. In this review, we begin by describing briefly the structure of MACPF proteins, outlining their common mechanism of pore formation. We subsequently discus...
متن کاملPerforin-2/Mpeg1 and other pore-forming proteins throughout evolution.
Development of the ancient innate immune system required not only a mechanism to recognize foreign organisms from self but also to destroy them. Pore-forming proteins containing the membrane attack complex Perforin domain were one of the first triumphs of an innate immune system needing to eliminate microbes and virally infected cells. Membrane attack complex of complement and Perforin domain p...
متن کاملCytoskeleton of apicomplexan parasites.
The Apicomplexa are a phylum of diverse obligate intracellular parasites including Plasmodium spp., the cause of malaria; Toxoplasma gondii and Cryptosporidium parvum, opportunistic pathogens of immunocompromised individuals; and Eimeria spp. and Theileria spp., parasites of considerable agricultural importance. These protozoan parasites share distinctive morphological features, cytoskeletal or...
متن کاملResponse : Mechanisms of perforin resistance : the differentiation between perforin binding and perforin - mediated lysis remains difficult
tomized patients. For example, pretransplantation disease duration was somewhat longer (albeit not significantly so) in splenectomized patients, and although not the case in the present study, disease duration has been found to be inversely correlated with posttransplantation outcome for other indications. In addition, splenectomized patients tended to be older and more often received a transpl...
متن کاملIntramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii.
Apicomplexan parasites actively secrete proteins at their apical pole as part of the host cell invasion process. The adhesive micronemal proteins are involved in the recognition of host cell receptors. Redistribution of these receptor-ligand complexes toward the posterior pole of the parasites is powered by the actomyosin system of the parasite and is presumed to drive parasite gliding motility...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2010
ISSN: 1942-0889
DOI: 10.4161/cib.3.1.9794