منابع مشابه
Apical hair cells and hearing.
This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise exposure, or the application of a cryoprobe...
متن کاملThe Apical Submembrane Cytoskeleton Participates in the Organization of the Apical Pole in Epithelial Cells
In a previous publication (Rodriguez, M.L., M. Brignoni, and P.J.I. Salas. 1994. J. Cell Sci. 107: 3145-3151), we described the existence of a terminal web-like structure in nonbrush border cells, which comprises a specifically apical cytokeratin, presumably cytokeratin 19. In the present study we confirmed the apical distribution of cytokeratin 19 and expanded that observation to other epithel...
متن کاملTransformation of polarized epithelial cells by apical mistrafficking of epiregulin.
Establishment and maintenance of apico-basolateral trafficking pathways are critical to epithelial homeostasis. Loss of polarity and trafficking fidelity are thought to occur as a consequence of transformation; however, here we report that selective mistrafficking of the epidermal growth factor receptor (EGFR) ligand epiregulin (EREG) from the basolateral to the apical cell surface drives trans...
متن کاملAdducins Regulate Remodeling of Apical Junctions in Human Epithelial Cells
Epithelial adherens junctions (AJs) and tight junctions (TJs) are dynamic structures that readily undergo disintegration and reassembly. Remodeling of the AJs and TJs depends on the orchestrated dynamics of the plasma membrane with its underlying F-actin cytoskeleton, and the membrane-cytoskeleton interface may play a key role in junctional regulation. Spectrin-adducin-ankyrin complexes link me...
متن کاملMore than apical: Distribution of SGLT1 in Caco-2 cells.
We investigated the distribution of the endogenous sodium-d-glucose cotransporter (SGLT1) in polarized Caco-2 cells, a model for enterocytes. A cellular organelle fraction was separated by free-flow electrophoresis and subjected to the analysis of endogenous and exogenous marker enzymes for various membrane vesicle components. Furthermore, the presence of SGLT1 was tested by an ELISA assay empl...
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ژورنال
عنوان ژورنال: Botanical Gazette
سال: 1913
ISSN: 0006-8071
DOI: 10.1086/331212