APhotorhabdusNatural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase
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منابع مشابه
A Photorhabdus Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase
Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipi...
متن کاملInhibition of insect juvenile hormone epoxide hydrolase: asymmetric synthesis and assay of glycidol-ester and epoxy-ester inhibitors of trichoplusia ni epoxide hydrolase.
Juvenile hormone (JH) undergoes metabolic degradation by two major pathways involving JH esterase and JH epoxide hydrolase (EH). While considerable effort has been focussed on the study of JH esterase and the development of inhibitors for this enzyme, much less has been reported on the study of JH-EH. In this work, the asymmetric synthesis of two classes of inhibitors of recombinant JH-EH from ...
متن کاملExpression and characterization of the recombinant juvenile hormone epoxide hydrolase (JHEH) from Manduca sexta.
The cDNA of the microsomal Juvenile Hormone Epoxide Hydrolase (JHEH) from Manduca sexta was expressed in vitro in the baculovirus system. In insect cell culture, the recombinant enzyme (Ms-JHEH) was produced at a high level (100 fold over background EH catalytic activity). As expected, Ms-JHEH was localized in the microsomal fraction with a molecular mass of approximately 50 kDa. Ms-JHEH showed...
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In vertebrates, the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) appears to play a role in neuronal development, synaptic plasticity, memory formation, and pituitary activity. However, functional NMDAR have not yet been characterized in insects. We have now demonstrated immunohistochemically glutamatergic nerve terminals in the corpora allata of an adult female cockroach, Diplopt...
متن کاملInsect Vitellogenesis in Juvenile Hormone-dependent Species
In most insects, vitellogenesis is regulated by juvenile hormone (JH). The recent cloning of the vitellogenin gene in a number of JH-dependent species has allowed the study of the induction of vitellogenin production by JH at a molecular scale. Potential JH response elements have been described in the regulatory regions of vitellogenin and other JHinducible genes. These elements may not only sh...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2015
ISSN: 1439-4227
DOI: 10.1002/cbic.201402650