AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation
نویسندگان
چکیده
منابع مشابه
Cooperative p16 and p21 action protects female astrocytes from transformation
Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism in retinoblastoma protein (Rb) activity was shown to block transformation of female, but not male, murine astrocytes in which neurofibromin and p53 function was abrogated (GBM astrocytes)....
متن کاملcompactifications and representations of transformation semigroups
this thesis deals essentially (but not from all aspects) with the extension of the notion of semigroup compactification and the construction of a general theory of semitopological nonaffine (affine) transformation semigroup compactifications. it determines those compactification which are universal with respect to some algebric or topological properties. as an application of the theory, it is i...
15 صفحه اولCDK4/6-inhibiting drug substitutes for p21 and p16 in senescence
CDKN1A (p21) and CDKN2A (p16) inhibit CDK4/6, initiating senescence. According to our view on senescence, the role of p21 and p16 is to cause cell cycle arrest, whereas MTOR (mechanistic target of rapamycin) drives geroconversion to senescence. Recently we demonstrated that one of the markers of p21- and p16-initiated senescence is MEK-dependent hyper-elevation of cyclin D1. We noticed that a s...
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In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arrested breast cancer cells and mitogen-mediated repression of the CDK inhibitor p21. AP4 directly r...
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Chen, Jun, Xuan Huang, Dorota Halicka, Sergey Brodsky, Ari Avram, Jonathan Eskander, Noah A. Bloomgarden, Zbigniew Darzynkiewicz, and Michael S. Goligorsky. Contribution of p16 and p21 pathways to induction of premature senescence of human endothelial cells: permissive role of p53. Am J Physiol Heart Circ Physiol 290: H1575–H1586, 2006. First published October 21, 2005; doi:10.1152/ajpheart.003...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2013
ISSN: 2041-4889
DOI: 10.1038/cddis.2013.282