منابع مشابه
Invadolysin opens many doors
Making a raft with oligomers pithelial cells differentially segregate proteins to their apical and basolateral surfaces. For some apical localization events, association of glycosylphosphatidylinositol (GPI)anchored proteins with detergent-resistant rafts is necessary but not sufficient. Now, on page 699, Paladino et al. show that the key for proper protein sorting may be the formation of high ...
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ceeding $150 million. Then come the operating expenses. When Feldmann began directing Health Canada’s BSL-4 lab in Winnipeg, Manitoba, he was cautioned by C. J. Peters to keep his operating funds separated from his research funds. While at USAMRIID, Peters went through a cold winter and the heating bill ate up much of the lab’s money. Unless a laboratory has long-term research goals and governm...
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The Energy Policy Act of 1992 embraces and implements many of the actions recommended by the President in the National Energy Strategy. .Independent geothermal power producers may be direct beneficiaries of 1) further deregulation of IPPs through their exemption from the provisions of the Public Utility Holding Company Act and 2) potentially freer access to utility-owned transmission facilities...
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It has been 20 y since the gene responsible for Huntington disease—a fatal neurodegenerative disorder—was identified by an intensive international collaborative effort (1). Although the features of the gene offered few clues to its normal function, the cloning of the IT15 gene immediately provided insight into the mechanism underlying disease: expansion of a CAG trinucleotide repeat within the ...
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Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and neurotransmission at low concentrations and a defensive cytotoxin at higher concentrations. The high active site conservation among all three NOS isozymes hinders the design of selective NOS inhibitors to treat inflammation, arthritis, stroke, septic shock and cancer. Our crystal structures and mutagene...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2005
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1576