Anxiety, depression, and behavioral symptoms of executive dysfunction in ecstasy users: Contributions of polydrug use

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Self-reports of executive dysfunction in current ecstasy/polydrug Users.

OBJECTIVES/BACKGROUND Ecstasy/polydrug users have exhibited deficits in executive functioning in laboratory tests. We sought to extend these findings by investigating the extent to which ecstasy/polydrug users manifest executive deficits in everyday life. METHODS Forty-two current ecstasy/polydrug users, 18 previous (abstinent for at least 6 months) ecstasy/polydrug users, and 50 non-users of...

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Meta-analysis of executive functioning in ecstasy/polydrug users.

Ecstasy/3,4-methylenedioxymethamphetamine (MDMA) use is proposed to cause damage to serotonergic (5-HT) axons in humans. Therefore, users should show deficits in cognitive processes that rely on serotonin-rich, prefrontal areas of the brain. However, there is inconsistency in findings to support this hypothesis. The aim of the current study was to examine deficits in executive functioning in ec...

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Evidence for selective executive function deficits in ecstasy/polydrug users.

Previous research has suggested that the separate aspects of executive functioning are differentially affected by ecstasy use. Although the inhibition process appears to be unaffected by ecstasy use, it is unclear whether this is true of heavy users under conditions of high demand. Tasks loading on the updating process have been shown to be adversely affected by ecstasy use. However, it remains...

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Gender differences in self-reported anxiety, depression, and somatization among ecstasy/MDMA polydrug users, alcohol/tobacco users, and nondrug users.

Previous research has found gender differences in both psychological and physiological responses to drugs. The present investigation explores gender variability in patterns of drug use in relation to self-reported depression, anxiety, and somatization. The current study confirms that heavy illegal drug users are represented by a preponderance of males than females. However, within each drug gro...

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The Differential Effects of Ecstasy - Polydrug use on Executive Components

Rationale/Objectives: Recent theoretical models suggest that the central executive may not be a unified structure. The present study explored the nature of central executive deficits in ecstasy users. Methods: In Study One, 27 ecstasy users and 34 nonusers were assessed using tasks to tap memory updating (computation span; letter updating) and access to long-term memory (a semantic fluency test...

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ژورنال

عنوان ژورنال: Drug and Alcohol Dependence

سال: 2007

ISSN: 0376-8716

DOI: 10.1016/j.drugalcdep.2006.09.003