Antiviral Activity of 3-Deazaguanine, 3-Deazaguanosine, and 3-Deazaguanylic Acid
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چکیده
منابع مشابه
Antiviral activity of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid.
3-Deazaguanine (ICN 4221), 3-deazaguanosine (ICN 4793), and 3-deazaguanylic acid (ICN 5412) represent a new class of synthetic guanine analogs having antiviral activity. In vitro, nine ribonucleic acid and seven deoxyribonucleic acid viruses were inhibited, including influenza, parainfluenza, rhino-, vesicular stomatitis, adeno-, herpes-, cytomegalo-, vaccinia, pseudorabies, and myxoma viruses....
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The nucleotide analog 7-deazaguanosine has not previously been reported to possess biological (antiviral or antitumor) properties in cell culture or in vivo. Up to 10(5) U of interferon per ml was detected in mouse sera 1 to 4 h following oral (200-mg/kg of body weight) and intraperitoneal (50-mg/kg) doses of the compound. 7-Deazaguanosine also caused significant activation of natural killer an...
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In L1210 cells in culture, 3-deazaguanine (DG), a relatively new purine analog, was found to inhibit DNA and protein synthesis but not total RNA synthesis. The effect of the drug on protein synthesis was therefore further examined. Polyadenylic acid-containing RNA synthesis was not decreased by DG treatment, suggesting that the inhibition of protein synthesis was a function of an alteration in ...
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In L1210 cells in culture, 3-deazaguanine (DG), a relatively new purine analog, was found to inhibit DNA and protein synthesis but not total RNA synthesis. The effect of the drug on protein synthesis was therefore further examined. Polyadenylic acid-containing RNA synthesis was not decreased by DG treatment, suggesting that the inhibiton of protein synthesis was a function of an alteration in t...
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The synthesis of SmCl3(THF)3 from SmCl3.6H2O is described. The reaction of SmCl3(THF)3 with NaBH4 in dry THF gave white microcrystalline tris (tetrahydroborato) tris (tetrahydrofuran) samarium (III), Sm(BH4)3(THF)3. The vibrational and magnetic properties of Sm(BH4)3...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1977
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.12.1.114