منابع مشابه
Photodynamic therapy for enhancing antitumour immunity.
BACKGROUND Photodynamic therapy (PDT) is a new modality in cancer treatment. It is based on the tumour-selective accumulation of a photosensitizer followed by irradiation with light of a specific wavelength. PDT is becoming widely accepted owing to its relative specificity and selectivity along with absence of the harmful side-effects of chemo and radiotherapy. There are three known distinct me...
متن کاملDectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells
Dectin-1 signalling in dendritic cells (DCs) has an important role in triggering protective antifungal Th17 responses. However, whether dectin-1 directs DCs to prime antitumour Th9 cells remains unclear. Here, we show that DCs activated by dectin-1 agonists potently promote naive CD4(+) T cells to differentiate into Th9 cells. Abrogation of dectin-1 in DCs completely abolishes their Th9-polariz...
متن کاملSTIM1 and STIM2-mediated Ca2+ influx regulates antitumour immunity by CD8+ T cells
Store-operated calcium entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels regulates the function of many immune cells. Patients with loss-of-function mutations in the CRAC channel genes ORAI1 or STIM1 are immunodeficient and are prone to develop virus-associated tumours. This and the reported role of Ca(2+) signals in cytotoxic lymphocyte function suggest that SOCE may be crit...
متن کاملAntitumour immune responses.
The role of the immune system in combating tumour progression has been studied extensively. The two branches of the immune response - humoral and cell-mediated - act both independently and in concert to combat tumour progression, the success of which depends on the immunogenicity of the tumour cells. The immune system discriminates between transformed cells and normal cells by virtue of the pre...
متن کاملTin-based Antitumour Drugs
We have been active in the synthesis and characterization of tin-based antitumour compounds for several years and we would like to summarize here the results that have already been patented(1) and that may therefore be disclosed(2). We synthesized some diorganotin 2,6-pyridinedicarboxylates.The dimethyltin compound has been found inactive in vitro, whereas the di-n-butyltin, di-t-butyltin and d...
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ژورنال
عنوان ژورنال: Nature
سال: 1974
ISSN: 0028-0836,1476-4687
DOI: 10.1038/250462b0