Antitubercular Activity Increase in Labdane Diterpenes from Copaifera Oleoresin through Structural Modification
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چکیده
منابع مشابه
Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria.
The antimicrobial activity of four labdane-type diterpenes isolated from the oleoresin of Copaifera langsdorffii as well as of two commercially available diterpenes (sclareol and manool) was investigated against a representative panel of microorganisms responsible for periodontitis. Among all the evaluated compounds, (-)-copalic acid (CA) was the most active, displaying a very promising MIC val...
متن کاملFive new labdane diterpenes from Aster oharai.
Five new labdane diterpenes (1-5) together with seven known diterpenes have been isolated from a methanol extract of the aerial parts of Aster oharai. Five new structures were determined as 7alpha-hydroperoxylabda-8(17),14-dien-13(R)-ol-4-O-acetyl-alpha-L-6-deoxyidopyranoside (1), 7alpha-hydroperoxylabda-8,14-dien-13(R)-ol-4-O-acetyl-alpha-L-6-deoxyidopyranoside (2), labda-7,14-dien-13(R)-ol-4-...
متن کاملAntifungal activity of Copaifera langsdorffii Desf oleoresin against dermatophytes.
Dermatophytoses are mycoses that affect keratinized tissues in both humans and animals. The aim of this study was to investigate the antifungal activity of the oleoresin extracted from Copaifera langsdorffii Desf. against the strains Microsporum canis ATCC 32903, Microsporum gypseum ATCC 14683, Trichophyton mentagrophytes ATCC 11481 and Trichophyton rubrum CCT 5507. The antimicrobial activity w...
متن کاملChemistry and biological activities of terpenoids from copaiba (Copaifera spp.) oleoresins.
Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biolog...
متن کاملBiological activities and cytotoxicity of diterpenes from Copaifera spp. Oleoresins.
Copaifera spp. are Amazonian species widely studied and whose oleoresins are used by local people for various medicinal purposes. However, a detailed study of the activity of the main phytochemical components of these oleoresins remains to be done. Here, we studied the cytotoxicity and in vitro anti-inflammatory effects of six diterpene acids: copalic, 3-hydroxy-copalic, 3-acetoxy-copalic, hard...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2016
ISSN: 0103-5053
DOI: 10.21577/0103-5053.20160268