Antitubercular activities, antioxidant properties and GCMS fingerprinting of <i>Acacia hebecladoides</i>, <i>Acacia albida</i> and <i>Gmelina arborea</i>.

Abstract Background : It is a practice to use traditional medicine for curing various illnesses in West Africa. Acacia hebecladoides , albida and Gmelina arborea were selected based on their belief treating ailments such as: hallucinations, inflammation tuberculosis. The study sought validate the antitubercular activity, antioxidant properties phytochemical components of extracts fractions leaves plants. Method: activities plants evaluated against Mycobacterium tuberculosis (MTB), multidrug-resistant (MDR-TB) non-mycobacterium (NTM) using Lowenstein Jensen (LJ) proportion method. Gas chromatography mass spectrometer (GCMS) assay assays (1,1- diphenyl -2-picryhydrazyl (DPPH) radical assay, total phenolic content (TPC), β-carotene bleaching activity nitric oxide scavenging activity) all carried out. Results: All three plant used inhibited with G. showing lowest MIC value 31.25μg/ml. Also, MDR-TB an 125μg/ml. most active plant, was fractionated into four partitions, (aqueous, n-hexane ethyl acetate) showed inhibitory MTB 62.5μg/ml. Also chloroform that acetate fraction had high activity. ethanolic extract A. while chloroform) DPPH aqueous content. its (aqueous n hexane) inhibition. Twelve compounds found as 2,3-dihydro-3,5,-6-methy 4H-Pyran-4-one 5-hydroxymethylfurfural abundant 35.81% 19.03% respectively, followed by 3,5-dihydroxy-2-methy-4H-Pyran-4-one (9.82%) n-Hexadecanoic acid (8.45%). Conclusions: out possess MDR-TB. activities.