Antithyroid autoantibodies in extrathyroid autoimmune diseases

This review summarizes data on the incidence of autoimmune diseases and examines prevalence antithyroid antibodies in extrathyroid diseases. In world, about 5–7% population suffers from one or another type Among six most common diseases, thyroid associated predominate. The high raises questions potential role course It is believed that are result interactions between triggers, autoantigens, genetic predisposition, impaired tolerance autoantigens mechanisms apoptosis. currently known autoantibodies, to thyroglobulin (TgAb), peroxidase (TPO), as well bispecific autoantibodies particular importance. Categories functionally significant mimic hormone function provoke development pathology a binding receptor subsequent stimulation thyrocytes include thyroid-stimulating (rTSH-Ab). Circulating against antigens not limited gland, but also found other often rheumatoid arthritis, 1 diabetes mellitus celiac disease. association with immune pathologies further confirms TPO were detected 15% patients asthma, 10–29% those idiopathic purpura vitiligo. slightly higher than TgAb, rTSH-Ab rarely registered non-thyroid immunological