Antithrombin III inhibits mesangial cell proliferation.
نویسندگان
چکیده
منابع مشابه
Antithrombin III Inhibits Mesangial Cell
Thrombin stimulates and heparin and heparan sulfate inhibit mesangial cell proliferation. In addition, heparin has been shown to inhibit thrombin-stimulated smooth muscle cell proliferation. The anticoagulant action of heparin is mediated by antithrombin Ill. This study investigated whether heparin’s antiproliferative action is also mediated by antithrombin Ill. To this end, the effect of antit...
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Thrombin has attracted increasing attention as a possible mitogen for vascular smooth muscle cells in lesion development both after vascular injury and in atherogenesis. In this study, the ability of antithrombin III to inhibit alpha-thrombin-induced DNA synthesis and cell proliferation in human arterial smooth muscle cells was analyzed. We demonstrate a concentration-dependent initiation of DN...
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BACKGROUND It has been reported that trifluoperazine (TFP) inhibits proliferation of cancer cells, however, the effects of TFP in renal proliferation diseases are still unclear. This study examined the effects of TFP on proliferation of human renal mesangial cells and analyzed the underlying mechanisms. MATERIAL AND METHODS Cell proliferation in vivo was determined by HE staining, immunohistoch...
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Mesangial cell (MC) proliferation is a key pathological feature in a number of common human renal diseases including IgA, systemic lupus erythematosus and diabetic nephropathies. Knowledge of the role of MCs in normal glomeruli and of their response to pathological stimuli is crucial to the understanding of these disease processes. The purpose of understanding disease is ultimately to develop t...
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Much work has recently focused upon the cellular involvement of the mesangium in glomerular inflammation and fibrosclerosis. A host of mediators of inflammation have been identified and their actions studied in mesangial cell cultures [1]. The recent identification of functional receptors for prostaglandins (PG) and thromboxane A2 (TxA2) in cultured glomerular mesangial cells [2, 3] has prompte...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1996
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v7102249