Antipsychotic treatment and neuregulin 1–ErbB4 signalling in schizophrenia
نویسندگان
چکیده
منابع مشابه
Antipsychotic treatment and neuregulin 1-ErbB4 signalling in schizophrenia.
Evidence from genetic, transgenic and post-mortem studies has strongly supported the critical role that neuregulin 1 (NRG1) and its ErbB4 receptor plays in the pathophysiology of schizophrenia. This article aims to review current evidence regarding the effects of antipsychotic treatment on NRG1-ErbB4 signalling. NRG1 and ErbB4 knockout mice display abnormal behaviours relevant to certain featur...
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Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in ...
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To the Editor: We read with great interest an important contribution by Gaebel et al1 in which they compared antipsychotic maintenance treatment with discontinuation and intermittent treatment in first-episode schizophrenia. We note several caveats in interpreting their crucial findings for well-balanced decision-making. The authors found that about half of patients in the intermittent treatmen...
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Schizophrenia is one of the most common global mental diseases, with prevalence of 1%. Patients with schizophrenia are predisposed to diabetes, coronary heart disease, hypertension, and osteoporosis, than the normal. In comparison with the metabolic syndrome, for instance, there are little reports about osteoporosis which occurs secondary to antipsychotic-induced hyperprolactinaemia. There are ...
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BACKGROUND The symptoms and signs of schizophrenia have been firmly linked to high levels of dopamine in specific areas of the brain (limbic system). Antipsychotic drugs block the transmission of dopamine in the brain and reduce the acute symptoms of the disorder. This review examined whether antipsychotic drugs are also effective for relapse prevention. OBJECTIVES To review the effects of ma...
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ژورنال
عنوان ژورنال: Progress in Neuro-Psychopharmacology and Biological Psychiatry
سال: 2011
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2011.04.002