ANTIPROLIFERATIVE ACTIVITY OF PYRROLIDINE DERIVATIVES COMPOUND IN COLON CANCER CELLS
نویسندگان
چکیده
Objective: Anti-cancer drug research plays an important role for chemotherapeutic treatments in various types of cancer. Pyrolidine derived compounds have been reported by many researchers to be a potent anti-cancer compound. It is aimed investigate the effects pyrolidine-derived that are thought new candidates with antiproliferative activity on DLD-1 and CCD-18CO cell lines. Material Methods: The pyrrolidine-derived compound was determined 24 hours at different concentrations (25-100 µM) (human colon cancer) (normal fibroblast) lines comparing MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5 Diphenyltetrazolium bromide) RTCA (real-time analysis) assays. significance differences between data sets assay analyzed statistically ANOVA SPSS 20.0 program Results: has reduce number cancer cells according negative control method suppress results. Thus, shown inhibit proliferation activity. Conclusion: Pyrrolidine-derived will first step studies guide next studies.
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ژورنال
عنوان ژورنال: Hitit medical journal
سال: 2021
ISSN: ['2687-4717']
DOI: https://doi.org/10.52827/hititmedj.924278