Antiproliferation Activity of a Small Molecule Repressor of Liver Receptor Homolog 1
نویسندگان
چکیده
منابع مشابه
Antiproliferation activity of a small molecule repressor of liver receptor homolog 1.
The orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) is a potent regulator of cholesterol metabolism and bile acid homeostasis. Recently, LRH-1 has been shown to play an important role in intestinal inflammation and in the progression of estrogen receptor positive and negative breast cancers and pancreatic cancer. Structural studies have revealed that LRH-1 can bind phospholipids...
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The orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) is a potent regulator of cholesterol metabolism and bile acid homeostasis. Recently, LRH-1 has been shown to play an important role in intestinal inflammation and in the progression of estrogen receptor positive and negative breast cancers and pancreatic cancer. Structural studies have revealed that LRH-1 can bind phospholipids...
متن کاملThyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1
BACKGROUND Expression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP expression by modulating the transcriptional activities of liver receptor homolog-1 (LRH-1). METHODS We injected thyroid hormone (triiodothyronine, T3) to C57BL/6J wild typ...
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The orphan nuclear receptor RORg is a key regulator for T helper 17 (TH17) cell differentiation, which regulates metabolic and circadian rhythm genes in peripheral tissues. Previously, it was shown that the small molecule inverse agonist of RORg SR1555 [1-(4-((49-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)[1,19-biphenyl]-4-yl)methyl)piperazin-1-yl) ethanone] suppressed TH17 differentiation an...
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The orphan nuclear receptor RORγ is a key regulator for T helper 17 (TH17) cell differentiation, which regulates metabolic and circadian rhythm genes in peripheral tissues. Previously, it was shown that the small molecule inverse agonist of RORγ SR1555 [1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl) ethanone] suppressed TH17 differentiation a...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2014
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.114.095554