Antioxidative Stress and Hepatoprotective Activities of Leaf Extract and Fractions of Setaria megaphylla in Plasmodium berghei Infected Mice

Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a perennial grass used traditionally in the treatment of various diseases such as malaria was, investigated for antioxidative stress activity Plasmodium berghei-infected mice. The leaf extract (200-600 mg/kg) and fractions (hexane, dichloromethane, ethyl acetate methanol; 400 S. were hepatoprotective activities mice using modified suppressive test model. Antioxidative potentials assessed by determining oxidative markers levels, liver function indices histopathology liver. extract/fractions progressively reduced parasitaemia induced chloroquine-sensitive P. berghei infection with methanol fraction exerting highest activity. caused significant (p<0.05 – 0.001) increases levels enzymes molecules (SOD, CAT, GPx, GSH) also MDA level significantly (p<0.05) livers treated-infected reduction (ALT, AST ALP), total conjugated bilirubin. Histology revealed absence or reductions pathological features treated infected compared to untreated may possess effects which part be mediated through chemical constituents plant.