Antioxidants help favorably regulate the kinetics of lipid peroxidation, polyunsaturated fatty acids degradation and acidic cannabinoids decarboxylation in hempseed oil
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چکیده
منابع مشابه
Effect of polyunsaturated fatty acids and antioxidants on lipid peroxidation in tissue cultures.
Lipid peroxidation was measured by the thio-barbituric assay for malondialdehyde (MDA). A small amount of MDA was formed when medial cells from guinea pig aorta were grown in tissue culture. The polyunsaturated fatty acids 8,11,14-eicosatrienoic acid, 5,8,11,14-eicosatetraenoic acid, and 7,10,13,16-docosatetraenoic acid generated significant amounts of MDA in a time-dependent manner when they w...
متن کاملFatty acids, lipid peroxidation and diseases.
Many studies have implicated oxygen radicals and lipid peroxidation in various diseases. Polyunsaturated fatty acids (PUFA) are believed to be one of the keys for understanding the damage that can be done to cells by free radicals. Free radical attack on PUFA may result in (1) the loss of PUFA which play important roles in cell membrane structure and as precursors for eicosanoid (prostaglandin ...
متن کاملRole of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments.
PURPOSE OF REVIEW The review aims at elucidating the role of lipid peroxidation of polyunsaturated fatty acids (PUFAs) in colorectal cancer (CRC) risk and treatment. RECENT FINDINGS CRC is one of the most overriding threats to public health. Despite a broad range of treatments, up to 50% of patients will inevitably develop incurable metastatic disease. Peroxidation of PUFAs contributes to aug...
متن کاملFive Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
I have been involved in research on polyunsaturated fatty acids since 1964 and this review is intended to cover some of the most important aspects of this work. Polyunsaturated fatty acids have followed me during my whole scientific career and I have published a number of studies concerned with different aspects of them such as chemical synthesis, enzymatic formation, metabolism, transport, phy...
متن کاملPeroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.
Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid peroxidase, cause lethal accumulation of lipid peroxides and induce ferroptotic cell death. Although ferroptosis has been suggested to involve accumulation of reactive oxygen species (ROS) in lipid environments, the m...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-67267-0