منابع مشابه
Antioxidants and myocardial contractility: illuminating the "Dark Side" of beta-adrenergic receptor activation?
Oxidant byproducts, such as superoxide anion (O2 ) and hydrogen peroxide, are produced as a consequence of normal aerobic metabolism. These molecules, which are highly reactive with other biological molecules, are referred to as reactive oxygen species (ROS). Under normal physiological conditions, ROS production is balanced by an efficient system of antioxidants, molecules that are capable of s...
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متن کاملMyocardial contractility and afterload in aortic stenosis
Background In aortic stenosis(AS) with normal left ventricular ejection fraction(LV EF), circumferential and longitudinal systolic strains(CSt, LSt) are reduced but the underlying mechanisms are uncertain. Conventional indices of afterload(A) per unit of myocardium are suboptimal for strain analysis and based on inaccurate assumptions about myocardial properties, while conventional contractilit...
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Animal studies have demonstrated that restoration of blood flow to severely ischemic myocardium is a prerequisite for myocardial salvage. However, it has been shown that the restoration of blood flow to ischemic myocardium may be associated with deleterious changes of the myocardium, including arrhythmias, enzyme release, and contractile dysfunction. These changes were considered to be addition...
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the cardiac action of phenoxybenzamine (dibenzyline) was studiedusing the maximum rate of pressure rise in the left ventricle as a measure of myocardial contractility. cardiac function was assessed by increasing the pressure load on the heart and measuring contractility as reflected by dp/dt. dibenzyline was found to change the cardiac response to pressure load. the rate of pressure increase in...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.103.6.782