ANTIOXIDANT THERAPY IN THE ELDERLY WITH TINNITUS: SYSTEMATICS REVIEW

Tinnitus is one of the most prevalent and annoying disorders that affect ear auditory system. It important symptoms in neurootology, along with hearing loss, vertigo, dizziness, nausea. can cause a variety somatic psychological interfere person's quality life. There correlation between oxidative stress tinnitus. Hair cell apoptosis, cochlear degeneration, alterations to supporting structures stria vascularis, changes nerve fibers acoustic nerve, irregular neuronal activity pathway, malfunction central cortex are all possible outcomes stress. Animal models aging, noise damage, ototoxicity have been used investigate relationship death hair cells. Antioxidants substances take on wide chemical structures, but they categorized as single class because share ability neutralize effects highly reactive potentially damaging free radicals. These radicals produced when foods undergo necessary oxidation reactions natural part digestion process. Antioxidant supplementation vitamins, minerals, phytochemicals, alpha-lipoic acid (ALA) might therapeutic tinnitus by reducing subjective discomfort level severity caused ringing ears.