Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination

An increase in peroxidation activity is considered as a nonspecific process characteristic of the pathogenesis various diseases accompanied by antioxidant deficiency. As bioregulators that can defense, antioxidants are important links multi-stage system regulation and coordination body functions. The structure function enzymes involved oxidative stress be significantly affected genetic polymorphism. To date, role genes encoding many remains unexplored, which great interest to researchers from fields. article presents review analysis data modern scientific literature on defense components metabolic processes, their determinant, summarizes methods for determination some antioxidants. When writing review, database electronic library eLibrary was used, keywords stress, free radical oxidation, protection, antioxidants, enzymes, enzyme genes, response element, research methods; filters – publication years 2012–2022, publications with full text, available viewing; English-language medical biological publications, created National Center Biotechnology Information (NCBI), lipid peroxidation, metabolism, methods.