Antioxidant, anti-inflammatory and anti-hyperglycemic activity of aqueous and methanolic extract of Houttuynia cordata: an in vitro and in vivo study

Available synthetic antioxidants such as butylated hydroxyl anisole, toluene, propyl gallate, and ascorbic acid exhibit several side effects. To curb these effects, more effective, less toxic, cost-effective drugs are required. Therefore, this study aims to screen evaluate the antioxidant well anti-inflammatory antidiabetic potential of Houttuynia cordata collected from Mairang village, West Khasi Hills, Meghalaya, India using standard methods. The aqueous methanolic extracts H. were evaluated by screening their ability scavenge 1,1-diphenyl-2-dipicrylhydrozyl, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid), hydrogen peroxide, nitric oxide. Total phenol flavonoid content was measured Folin-Ciocalteau AlCl3 colorimetric method respectively. activity plant determined protein denaturation method. Methanolic varying free radical scavenging activity. Among used in study, extract elicited a higher than extract. also marked reduction blood glucose level normal alloxan-induced diabetic mice. Flavonoids, which have been reported possess anti-inflammatory, enzyme inhibition, antimicrobial, anticancer, antiallergy, properties may contribute towards effect cordata.