Antioxidant and hypoglycemic activities of various solvent fractions of methanol extract of Terminalia alata Heyne ex Roth trunk-bark

The antioxidant and hypoglycemic capacities of various solvent fractions from the trunk-bark methanol extract Terminalia alata Heyne ex Roth (T. alata) were investigated. DPPH radical scavenging assay was used to evaluate activity, methods for determination digestive enzymes inhibitory activity fasting blood glucose reduction capacity in diabetic rats determine fractions. results indicated that higher total phenolics content measured with increasing polarity extraction coincided content. Ethyl acetate fraction (EAF), n-butanol (BF), water (WF) obtained. They possessed α-amylase inhibition IC50 values 0.056 ± 0.001, 0.138 0.005, 0.022 0.001 mg.mL-1, respectively, which lower than acarbose (IC50 = 0.154 0.02 mg.mL-1). In contrast, α-glucosidase activities these those acarbose. addition, also lowered concentrations streptozotocin induced at a dose 200 mg.kg-1 bw (body weight) without inducing body weight loss, not observed when treating EAF WF T. are recommended as potent sources further research on activities.