Antinuclear antibodies in primary pulmonary hypertension

Evaluation of Pulmonary Hypertension In First Degree Relatives Of Patients With Primary Pulmonary Hypertension

Background: Pulmonary hypertension (PH) was defined for the first time in 1951 as primary pulmonary hypertension (PPH). Some studies emphasized on the role of genetics in the development of pulmonary hypertension in family members of affected patients. So, in this study we evaluated the prevalence of pulmonary hypertension in first degree family of patients with documented PPH. Methods: In thi...

Antinuclear Antibodies

knowledge of gene regulation, particularly in neoplastic cells, this deficit is striking. With our current understanding of chromosomal translocations, point mutations, and gene amplification in tumor cells, it is surprising to read that there is ". . . no difference between cancer and normal DNA . . ." (p. 130). The author spends a fair amount of time discussing possible mechanisms for the car...

Antinuclear antibodies associated with pulmonary involvement in systemic sclerosis.

In response to Dr. Homasson, my comments are as follows: 1) Mv paper is about a personal experience with laser bronchoscopy Ofll\ 2) In the introductii)n, I mentioned a statenient by Dr. Shapshav drawn from reference 1 of my paper. 3) I have flO personal experience with that technique and therefore I am unable to judge Dr. Honiasson’s letter. I think Dr. Shapshay or Dr. Sanderson, who initiated...

Hypertrophic Pulmonary Osteoarthropathy with Positive Antinuclear Antibodies: Case Report

A male Afro-descendant patient, 57 years old, complaining of polyarticular involvement and weight loss for 18 months, with a load of 13.5 pack years of smoking. On physical examination there was pain on palpation of the right knee and right leg, with signs of inflammation on the knee. We also observed digital clubbing in all fingers. Antinuclear antibodies (ANA) and anti-Sm antibodies were posi...

Antinuclear antibodies in systemic sclerosis