Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors
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چکیده
منابع مشابه
Delta opioid receptor enhancement of mu opioid receptor-induced antinociception in spinal cord.
Although the mu selective agonist [D-Ala2-MePhe4-Gly-ol5]enkephalin (DAMGO) and the delta selective agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) are both antinociceptive when administered directly into the spinal cord of mice, 50% of antinociceptive dose (AD50) of DAMGO is about 2 orders of magnitude lower than the AD50 of DPDPE. In contrast, the two ligands show similar affinities for their respe...
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The present study was conducted on rats with inflammation induced by subcutaneous injection of carrageenan into the left hindpaw. Intrathecal administration of oxytocin produced dose-dependent increases in the hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with inflammation. The antinociceptive effect of oxytocin was blocked by intrathecal administration of atosi...
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We recently discovered that the activation of the spinal glucagon-like peptide-1 receptors (GLP-1Rs) by the peptidic agonist exenatide produced antinociception in chronic pain. We suggested that the spinal GLP-1Rs are a potential target molecule for the management of chronic pain. This study evaluated the antinociceptive activities of geniposide, a presumed small molecule GLP-1R agonist. Genipo...
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Budai, Dénes and Howard L. Fields. Endogenous opioid peptides horn nociceptive neurons remain unclear, largely because acting at m-opioid receptors in the dorsal horn contribute to midthe laminae that receive direct RVM input contain several brain modulation of spinal nociceptive neurons. J. Neurophysiol. different neural elements including the terminals of primary 79: 677–687, 1998. Activation...
متن کاملEndogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Activation of neurons in the midbrain periaqueductal gray (PAG) inhibits spinal dorsal horn neurons and produces behavioral antinociception in animals and analgesia in humans. Although dorsal horn regions modulated by PAG activation contain all three opioid receptor classes (mu, delta, and kappa), as well as enkephalinergic interneurons and terminal fields, descending opioid-mediated inhibition...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1996
ISSN: 0007-0912
DOI: 10.1093/bja/77.6.758