Antineoplastic Therapies related Cardiotoxicity
نویسندگان
چکیده
منابع مشابه
Target therapies-induced Cardiotoxicity
Target therapies have become an important component of the treatment of many cancers, with significant evidence of a gain in survival in their use, but at the same time, with increasing concern about their ability to cause a wide spectrum of secondary cardiovascular adverse events (left ventricular dysfunction, heart failure, hypertension, ischaemic heart disease, QT prolongation, sudden cardia...
متن کاملAntineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective
Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX. Chemoterapeutic agents can alter redox homeostasis by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species RNS. Cellular sources of ROS/RNS are cardiomyocytes, endothelial cells, stromal and...
متن کاملA Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect...
متن کاملCancer Therapy Related Cardiotoxicity
In the last two decades, significant advances in cancer therapy development have lead to more effective chemotherapeutic and novel targeted therapies for cancer patients. Although this has resulted in a remarkable improvement in cure rates and cancer-related survival, it has also resulted in unwanted long term side effects in a growing population of survivors. In recent years, cardiac toxicity ...
متن کاملAntineoplastic-related cardiotoxicity, morphofunctional aspects in a murine model: contribution of the new tool 2D-speckle tracking
OBJECTIVE Considering that global left ventricular systolic radial strain is a sensitive technique for the early detection of left ventricular dysfunction due to antineoplastics and the analysis of segmental myocardial contractility, we evaluated this technique for early detection of trastuzumab-related cardiotoxicity by comparing it with cardiac structural damage. METHODS Groups of six mice ...
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ژورنال
عنوان ژورنال: Madridge Journal of Internal and Emergency Medicine
سال: 2019
ISSN: 2638-1621
DOI: 10.18689/mjiem-1000131