ANTIMIGRAINE ACTIVITY OF METHANOLIC EXTRACT OF ABROMA AUGUSTA L. IN LABORATORY ANIMALS

Objective: The present study aimed to evaluate of antimigraine activity methanolic extract Abroma augusta L. leaves in laboratory animals. Methods: was evaluated against nitroglycerine (NTG, 10 mg·kg−1, i. p.) and bradykinin (BK, µg, intra-arterial) induced hyperalgesia rats. Rats were divided randomly into six groups: normal, control, standard (sumatriptan, 42 s. c.), (100,200 400 p. o.). In the nitroglycerin (NTG) model, rats pre-treated with drug sumatriptan for 0, 7 14 d tail flick latency recorded separately 0-day, 7-day 14-day pretreatment study. Brain serotonin concentration also estimated by HPLC method at end model number vocalizations as a measure Results: showed significant (P<0.001) elevation tail-flick (at dose mg·kg−1) body weight doses 100, 200, NTG-induced Further, A. (400 mg/kg) increase brain compared NTG control group animal. It (P<0.01, P<0.001) reduction elevated (200 bradykinin-induced Conclusion: We concluded that Aroma possessed an anti-migraine effect