Antimicrobial Peptides: Mechanisms of Action and Resistance
نویسندگان
چکیده
منابع مشابه
Mechanisms of antimicrobial peptide action and resistance.
Antimicrobial peptides have been isolated and characterized from tissues and organisms representing virtually every kingdom and phylum, ranging from prokaryotes to humans. Yet, recurrent structural and functional themes in mechanisms of action and resistance are observed among peptides of widely diverse source and composition. Biochemical distinctions among the peptides themselves, target versu...
متن کاملAntibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance
Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can induce chemokine production, accelerate angiogenesis, and wound healing and modulate apoptosis in multicellular organisms. Originally, their antimicrobial mechanism of action was thought to consist solely of an inc...
متن کاملAntimicrobial resistance: Mechanisms of action of antimicrobial agents
Microorganisms coexist with other living organisms and exhibit the greatest genetic and metabolic activity. Microbes have evolved various mechanisms to survive pressure exerted by competitive environmental challenges. Infection is the invasion of the host by harmful microorganisms (microbial pathogens), which then multiply in close association with the host's tissues. Infections may differ in s...
متن کاملMechanisms and consequences of bacterial resistance to antimicrobial peptides.
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial activity. Because of the increased frequency of resistance to conventional antibiotics there is an interest in developing AMPs as an alternative antibacterial therapy. Several cationic peptides that are derivatives of AMP...
متن کاملAntimicrobial peptides in action.
Molecular dynamics simulations of the magainin MG-H2 peptide interacting with a model phospholipid membrane have been used to investigate the mechanism by which antimicrobial peptides act. Multiple copies of the peptide were randomly placed in solution close to the membrane. The peptide readily bound to the membrane, and above a certain concentration, the peptide was observed to cooperatively i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2016
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034516679973