Antimicrobial Effect of Titanium Oxide (Tio2) Nano Particles in Completely Edentulous Patients. A Randomized Clinical Trial.

Objective: to investigate the effect of addition different concentration TiO2  nanoparticles  on acrylic resin polymethyl methacrylate improve the  anti-microbial properties denture base material Subjects and Methods: 24 completely edentulous patients were selected be enrolled in following groups:  Group I: 8 rehabilitated with complete  dentures had no nanoparticle (Control group),Group II: dentures a 1% titanium oxide nanoparticles III: 3% . Microbiological evaluation was done from fitting surface after one week, two weeks, month  of use. Results: Regarding staphylococcus aureus candida albicans colonization, result revealed that between  weeks , and  month  follow up periods  for each group between groups period, there statistically significant difference all groups. epidermis colonization negative Conclusion: Addition TiO2 nano particles 3%  concentrations to  PMMA has great reduction S. aureus, C. than conventional