Antimicrobial biomaterials with non‐antibiotic strategy
نویسندگان
چکیده
منابع مشابه
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells*
Fluoroquinolones (FQ) are powerful broad-spectrum antibiotics whose side effects include renal damage and, strangely, tendinopathies. The pathological mechanisms underlying these toxicities are poorly understood. Here, we show that the FQ drugs norfloxacin, ciprofloxacin, and enrofloxacin are powerful iron chelators comparable with deferoxamine, a clinically useful iron-chelating agent. We show...
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Tetracyclines are broad-spectrum antibiotics that act as such at the ribosomal level where they interfere with protein synthesis. They were first widely prescribed by dermatologists in the early 1950s when it was discovered that they were effective as a treatment for acne. More recently, biologic actions affecting inflammation, proteolysis, angiogenesis, apoptosis, metal chelation, ionophoresis...
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The importance of surveillance* in combating and managing antimicrobial† resistance (AMR) is recognised as an important component of the World Health Organization (WHO) Global Strategy for Containment of Antimicrobial Resistance, 2001. There is good evidence that surveillance is a costeffective infection control strategy.1,2 Appropriate surveillance provides vital information for the targeting ...
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tion of metals have been reported to cause reacBiocompatibility can be defined as the ability tions, which most typically manifest as hives, of a biomaterial to demonstrate host and material eczema, redness, and itching (6,9–11). Although response appropriate to its intended application little is known about the shortand long-term (1). The determination of biocompatibility has pharmacodynamics ...
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ژورنال
عنوان ژورنال: Biosurface and Biotribology
سال: 2019
ISSN: 2405-4518,2405-4518
DOI: 10.1049/bsbt.2019.0010