Antimicrobial activity and quality control of a formulation based on Libidibia ferrea after aging

This study aimed to evaluate in vitro the pharmacological stability of a herbal mouthwash based on Libidibia ferrea extract after aging, establishing its organoleptic and microbiological characteristics. It is 7.5% hydroalcoholic from pods, using reflux decoction technique, spray dried. The stability, pH, sedimentation, density, antimicrobial activity tests were performed with solutions stored 24 months. Contaminant control was carried out by determining total number microorganisms researching Salmonella sp., Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus. formulation's against present dental biofilm analyzed: Streptococcus mutans, salivarius, Lactobacillus casei, Candida albicans., data analyzed Tukey test assess pH other results described descriptive statistics., color observed characters, “Ceramics”, fluid/serous consistency, shiny appearance, strong minty, woody odor. In sedimentation phase, separation observed, density analyzes showed mean value 5.46 1.029 g/cm3, respectively. contaminant assessment negative for all surveyed, within bactericidal/fungicidal tested at concentrations S. mutans C. albicans. At 0.5 mg/ml salivarius 0.6 L casei. concluded that months, formulation L. ferrea, initial characteristics remained stable except homogeneity solution.