Antimetabolites for all?
نویسندگان
چکیده
منابع مشابه
A Study of Antimetabolites
Pettus gave everything he had as a medical missionary in China and Dr. Edward H. Hume has drawn a clear and sympathetic picture of this man, his aspirations, and those qualities which distinguished him as a medical scientist at home and abroad. On 23 November 1945 was received the melancholy cablegram from Huangping, China, which read as follows: "Dr. Pettus killed in airplane accident at Huang...
متن کاملThe need for additional alkylating agents and antimetabolites.
The title that was assigned to me is a clear invitation to pontificate. Instead, I will share with you a few modest and not very original thoughts and speculations. These are based on a large literature and a small experience of tilling the soil among certain obscure and unnatural pyrimidines. This engage ment with the rationality of antimetabolites followed an ignoble exodus from the quagmire ...
متن کاملStudies of Antimetabolites* Ii. I-acetylpyridine
When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...
متن کاملStudies of antimetabolites. II. 3-Acetylpyridine.
When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...
متن کاملProblems in the Designing of Antimetabolites †
Historically, the most useful medicinal agents have been obtained by empirical screening or by the chemical modification of compounds of known activity in the hope of making them more effective. To these approaches a new one was added in recent years-antimetabolites. An antimetabolite may be defined as a compound bearing structural resemblance to a metabolite and capable of being attached to th...
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ژورنال
عنوان ژورنال: Eye
سال: 1997
ISSN: 0950-222X,1476-5454
DOI: 10.1038/eye.1997.200