Antiinflammatory and antioxidant effects of gemcitabinein collagen-induced arthritis model

Antiinflammatory and antioxidant effects of gemcitabine in collagen-induced arthritis model.

BACKGROUND/AIM Gemcitabine (GEM) has antiproliferative effects on lymphocytes, which are potent pathogenic actors of rheumatoid arthritis (RA). The aim of the study was to investigate the therapeutic potential of GEM on collagen-induced arthritis (CIA). MATERIALS AND METHODS Arthritis was induced by the intradermal injection of chicken type II collagen with incomplete Freund's adjuvant into a...

Antioxidant and Antiinflammatory Effects of Vitex Negundo on Freund’s Complete Adjuvant Induced Arthritis

Objective: Vitex negundo, commonly known as “nirgundi” is widely used in traditional as well as in folk medicines to cure many ailments such as fever, rheumatism, gum and skin diseases and liver disorders, etc. The present study evaluated the antioxidant potency of hydroethanolic extract of Vitex negundo leaves (VNE) in Freund’s complete adjuvant (FCA) induced arthritis. Methods: Acute oral tox...

Collagen Antibody Induced Arthritis

Amelioration of Collagen-Induced Arthritis

Effects of cyclosporin on collagen induced arthritis in mice.

We have studied the effect of the immunosuppressive agent cyclosporin on collagen induced arthritis in mice. Cyclosporin, when given prophylactically, was capable of suppressing the development of collagen induced arthritis and the immunological response to native type II collagen in a dose dependent manner. Furthermore, treatment with cyclosporin, started on the same day as the booster injecti...