Anti‐IL‐5 in pediatric allergic diseases

Leukotrienes and leukotriene modifiers in pediatric allergic diseases

Leukotrienes are potent pro-inflammatory lipid mediators derived from arachidonic acid through several enzymatic pathways. They have an essential role in allergic inflammation, where they induce bronchoconstriction, airway edema, and chemotaxis of the inflammatory cells in the airways, nasal and conjunctival tissues. Leukotriene modifiers include leukotriene receptor antagonists (montelukast, z...

Basic Mechanisms in Allergic Diseases

This review will describe certain developments which have appeared recently in the immunologic literature involving the transfer of viable cells from one animal to another. In 1940 Landsteiner and Chase showed that it was possible to remove cellular exudates from guinea pigs sensitized with simple chemical compounds, wash these cells and transfer them to fresh guinea pigs and then to demonstrat...

Soluble CD23 in allergic diseases.

CD23, a differentiation marker of B cells is identified with the low-affinity receptor for IgE--FcepsilonRII. The CD23 molecule is continuously cleaved by autoproteolysis into soluble fragments called sCD23, considered as a multifunctional cytokine. sCD23 is supposed to play an important role in IgE synthesis. IgE is a hallmark of atopy and its overproduction is a characteristic feature of alle...

[Mast cells in allergic diseases].

Allergic diseases in the elderly

Demographic distribution of the population is progressively changing with the proportion of elderly persons increasing in most societies. This entails that there is a need to evaluate the impact of common diseases, such as asthma and other allergic conditions, in this age segment. Frailty, comorbidities and polymedication are some of the factors that condition management in geriatric patients. ...