Antihistamine antinociception is mediated by Gi-protein activation
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منابع مشابه
Thioperamide-induced Antinociception is Mediated through Endogenous Opioid System in the Dentate Gyrus of Adult Rats
The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 μl, 2.5 %) in the ventral surface of right hind paw produced a biphasic pattern (first phase: 0-5 min and second phase: 15 - 60 min) of licking/biting an...
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متن کاملGi-mediated stimulation of type II adenylyl cyclase is augmented by Gq-coupled receptor activation and phorbol ester treatment.
Synergism between Gs- and Gi- or Gq-dependent signaling pathways has been demonstrated in the stimulation of type II adenylyl cyclase (AC-II). Provision of activated alpha s is known to allow numerous Gi-coupled receptors to stimulate AC-II and to potentiate the responses to Gq-coupled receptors. To explore possible interactions between Gi- and Gq-coupled receptors that are independent of alpha...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2002
ISSN: 0306-4522
DOI: 10.1016/s0306-4522(01)00537-1