ANTIHELMINTIC POTENTIAL OF CORIANDER ESSENTIAL OIL (CORIANDRUM SATIVUM L.) IN SHEEP

The development of anthelmintic resistance in sheep gastrointestinal nematodes to commercial anthelmintics has led enormous economic losses many parts the world. For this reason, new sustainable strategies for control these parasites are being actively searched, which include use different alternatives such as plant essential oils. aim study was determine chemical composition oil coriander (Coriandrum sativum L.) and test its potential against sheep. Qualitative semi-quantitative characterization performed using gas chromatography coupled with mass spectrometric detection (GC-MS analysis). tested vitro egg hatching (EHT), carried out eight concentrations (50; 12.5; 3.125; 0.781; 0.195; 0.049; 0.025 0.0125 mg/mL). Thiabendazole mg/mL used positive control, emulsifier 3% Tween 80 v/v distilled water negative control. GC-MS analyzes revealed a rich oil, where total 17 ingredients from groups were found, 15 identified. dominant ingredient linalool (84.5%) along γ-terpinene (5.04%),camphor (3.26%) α-pinene (2.88%). EHT results showed high inhibition larval hatching, i.e. an ovicidal effect 29.0-88.7% depending on concentration, IC50 concentration 0.04 clear dose-dependent (R2= 0.90). This confirmed possible importance botanical animals fight resistance. obtained indicate role future therapeutic approaches infections caused by sheep, after further vivo tests toxicity studies.