Antigenicity Studies on Salk-type Poliomyelitis Vaccine

The 1954 Salk poliomyelitis vaccine field trial.

Experimental study of interference between Pertussis antigens and Salk Poliomyelitis vaccine

TIIE BIGGEST PUBLIC IIEALTH EXPERIMENT EVER: The 1954 Field Trial of the Salk Poliomyelitis Vaccine

THE LARGEST and most expensive medical experiment in history was carried out in 1954. Well over a million young children participated, and the immediate direct costs were over 5 million dollars. The experiment was carried out to assess the effectiveness, if any, of the Salk vaccine as a protection against paralysis or death from poliomyelitis. The study was elaborate in many respects, most prom...

Poliomyelitis Vaccine

The Epidemiology of poliomgelitis has been investigated in our country Pasteur Institute; the incidence of Poliomgelitis, after the age of 4 years i's rare, in Iran.  Passive antibody of maternal origin do not interfere with production of active antibody after immunization.  Inactivated Polio Vaccine (salk) has been effective in reducing the incidence of poliomge­litis by approximately 90 per ...

Studies on Antigenicity

The enzymatic degradation of fluorescein conjugates of poly-L-lysine, poly-D-lysine, and exhaustively succinylated poly-L-lysine by aqueous extracts of spleens from "responder" (guinea pigs which can develop immune responses to hapten-poly-L-lysine conjugates) and "non-responder" guinea pigs was investigated. The in vivo degradation of H(3)-tagged dinitrophenyl conjugates of these synthetic pol...