Antigen 85 variation across lineages of Mycobacterium tuberculosis—Implications for vaccine and biomarker success
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چکیده
منابع مشابه
Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen
The increasing prevalence of drug-resistant tuberculosis highlights the need for identifying new antitubercular drugs that can treat these infections. The antigen 85 (Ag85) complex has emerged as an intriguing mycobacterial drug target due to its central role in synthesizing major components of the inner and outer leaflets of the mycobacterial outer membrane. Here we identify ebselen (EBS) as a...
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Leila de Mendonga Lima, Jean Content, Hugo van Heuverswyn and Wim Degrave* Department of Biochemistry and Molecular Biology and Laboratory of Hanseniasis, Department of Tropical Medicine, Oswaldo Cruz Institute, FIOCRUZ, Av. Brasil 4365, Rio de Janeiro, RJ, CEP 21045, Brasil, lnstitut Pasteur du Brabant, Department of Virology, B-1180 Brussels and lnnogenetics, Industriepark Zwijnaarde 7, box 4...
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Background: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB). Bacille Calmette-Guerin (BCG) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult TB vaccine. The aim of this study was to develop a new tuberculosis DNA vaccine candidate encoding a recombinant HspX-PPE44-EsxV fusion antigen of M. tuberculosis. Methods: ...
متن کاملThe Genes Coding for the Antigen 85 Complexes of Mycobacterium tuberculosis and Mycobacterium bovis BCG Are Members of a Gene Family: Cloning, Sequence Determination, and Genomic Organization of the Gene Coding for Antigen 85-C of M. tuberculosis
and genomic organization of the gene coding gene family: cloning, sequence determination, Mycobacterium bovis BCG are members of a of Mycobacterium tuberculosis and The genes coding for the antigen 85 complexes A gene encoding the 33-kDa secreted protein of Mycobacterium tuberculosis (antigen 85-C) was isolated and sequenced. The corresponding DNA sequence contains a 1,020-bp coding region. The...
متن کاملPossible association of GroES and antigen 85 proteins with heat resistance of Mycobacterium paratuberculosis.
Conflicting reports on the heat resistance of Mycobacterium paratuberculosis prompted an examination of the effect of culture medium on this property of the organism. M. paratuberculosis was cultured in three types of media (fatty acid-containing medium 7H9-OADC (oleic acid-albumin-dextrose-catalase supplement) and glycerol-containing media WR-GD and 7H9-GD [glycerol-dextrose supplement]) at pH...
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ژورنال
عنوان ژورنال: Journal of Proteomics
سال: 2014
ISSN: 1874-3919
DOI: 10.1016/j.jprot.2013.07.005