Antiepileptic potential of <i>Silybum marianum</i> seeds in pentylenetetrazol-induced kindled mice
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چکیده
منابع مشابه
Ivabradine Reduces Seizures in Pentylenetetrazol- Kindled Mice
Methods: Forty Mice were randomly allocated into 4 equal groups; control, PTZ, diazepam (4mg/kg) and ivabradine (10 mg/kg) groups. Kindling model was produced by repeated i.p. administration of PTZ (40mg/kg), every other day for 9 days. Repeated PTZ treatment progressively increased the seizure score with the maximum score reached on day 9. Diazepam and ivabradine were administered intraperiton...
متن کاملMontelukast reduces seizures in pentylenetetrazol-kindled mice.
Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phen...
متن کاملAntiepileptic and Antioxidant Effect of Brassica nigra on Pentylenetetrazol-Induced Kindling in Mice
Considering the high rate of epilepsy today, with respect to the insufficiency of the available therapies, new strategies and methods are recommended for medical treatment of epileptic patients. Therefore, the present study experimentally investigated the anticonvulsant effect of a herbal medicine candidate brassica nigra, by using kindling method. Sixty male mice were randomly selected and div...
متن کاملAntiepileptic and Antioxidant Effect of Brassica nigra on Pentylenetetrazol-Induced Kindling in Mice
Considering the high rate of epilepsy today, with respect to the insufficiency of the available therapies, new strategies and methods are recommended for medical treatment of epileptic patients. Therefore, the present study experimentally investigated the anticonvulsant effect of a herbal medicine candidate brassica nigra, by using kindling method. Sixty male mice were randomly selected and div...
متن کاملEffects of sildenafil on pentylenetetrazol-induced convulsions in mice and amygdala-kindled seizures in rats.
Sildenafil is the first marketed phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction and recently, for pulmonary hypertension. While the treatment was found to be highly effective, several adverse effects are associated with this compound. Among numerous central nervous system-related untoward effects, proconvulsant activity was reported. The purpose of this study was to ass...
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ژورنال
عنوان ژورنال: Bangladesh Journal of Pharmacology
سال: 2016
ISSN: 1991-0088
DOI: 10.3329/bjp.v11i3.26181