Antiepileptic drug exposure in pregnancy and pregnancy outcome from national drug usage data
نویسندگان
چکیده
منابع مشابه
Antiepileptic drug exposure in pregnancy and pregnancy outcome from national drug usage data.
BACKGROUND Antiepileptic drugs (AEDs) are used by pregnant women to manage conditions such as epilepsy and bipolar disorder even though they pose a risk to the developing foetus. This study aimed to determine the overall use of AEDs by women during their childbearing years and women who are pregnant and the association between AED use and rates of pregnancy termination and spontaneous abortion....
متن کاملNorth American antiepileptic drug pregnancy registry.
Background: The North American AED (antiepileptic drug) Pregnancy Registry was established in 1997 for pregnant women in the United States and Canada at the Massachusetts General Hospital in Boston, Massachusetts. The major objective was to obtain, as quickly as possible, information on the frequency of major malformations among infants whose mothers had taken one or more AEDs to prevent seizur...
متن کاملAntiepileptic drug use during pregnancy: Perinatal outcomes
PURPOSE This study was undertaken to (1) measure the frequency of AED monotherapy or polytherapy during pregnancy and AED discontinuation prior to pregnancy in a cohort of women with treated epilepsy; and (2) describe the frequency of major congenital malformations according to maternal use of AED during pregnancy. METHODS A cohort of epileptic pregnant women was identified within the Quebec ...
متن کاملSafety of the newer antiepileptic drug oxcarbazepine during pregnancy.
OBJECTIVE Seizure control in pregnant women with epilepsy is vital, as maternal seizures may have deleterious consequences. The treatment of pregnant women with epilepsy is, however, complicated by the teratogenicity of older antiepileptic drugs (AEDs). In this review, the safety of the newer AED oxcarbazepine during pregnancy is assessed based on published pregnancy outcome data. Other relevan...
متن کاملAntiepileptic drug pregnancy registries: do the latest findings concur?
Registry versus clinical trial The main goal of pregnancy registries includes the rapid identification of signals of increased teratogenic risk as quickly as possible, which is especially important for newly available anti epileptic drugs (AEDs) [1–3]. When the association between an increased risk and an AED is found in a registry, the cause can be further explored in a case–control study or a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Pregnancy and Childbirth
سال: 2018
ISSN: 1471-2393
DOI: 10.1186/s12884-018-1728-y