Antidiabetic activity of Coccinia grandis (L.) Voigt: Bioactive constituents, mechanisms of action, and synergistic effects
نویسندگان
چکیده
Phytochemical investigations and antibacterial activity of some medicinal plants against pathogenic bacteriaB. Jayalakshmi, K. A. Raveesha, N. Amruthesh
منابع مشابه
Antiproteolytic and leishmanicidal activity of Coccinia grandis (L.) Voigt leaf extract against Leishmania donovani promastigotes.
In visceral leishmaniasis (VL), development of alternative safe therapeutic strategy is gaining paramount wherein natural components of plant origin have prominence. We explored Coccinia grandis (L.) Voigt, a medicinal plant known in traditional folk medicine, for its antileishmanial efficacy. SDS-PAGE analysis of the C. grandis leaf extract (Cg-Ex) showed few protein bands about 14-66 kDa amon...
متن کاملAntimicrobial activity of protease inhibitor from leaves of Coccinia grandis (L.) Voigt.
Antimicrobial activity of protease inhibitor isolated from Coccinia grandis (L.) Voigt. has been reported. A 14.3 kDa protease inhibitor (PI) was isolated and purified to homogeneity by ammonium sulfate precipitation (20-85% saturation), sephadex G-75, DEAE sepharose column and trypsin-sepharose affinity chromatography from the leaves of C. grandis. The purity was checked by reverse phase high ...
متن کاملProtease Inhibitors from Coccinia Grandis (l.) Voigt. Leaves: Purification, Characterization and Kinetic Properties
Cucurbits are rich source of protease inhibitors. A protein of 14.3 kDa designated as Coccinia grandis protease inhibitors (CGPI) was isolated from leaves of Coccinia grandis and purified to homogeneity by ammonium sulfate precipitation, Sephadex G-75 column, DEAE Sepharose column and TrypsinSepharose affinity chromatography. The purity was checked by reversed phase chromatography. The molecula...
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Pomegranate fruit presents strong anti-inflammatory, antioxidant, antiobesity, and antitumoral properties, thus leading to an increased popularity as a functional food and nutraceutical source since ancient times. It can be divided into three parts: seeds, peel, and juice, all of which seem to have medicinal benefits. Several studies investigate its bioactive components as a means to associate ...
متن کاملBlood Sugar Lowering Effect of Coccinia grandis (L.) J. Voigt: Path for a New Drug for Diabetes Mellitus
BACKGROUND Role of herbs in the management and control of diabetes has emerged fast over the years. We assessed the efficacy of Coccinia grandis (locally known as Ken, Kovakka) leaves as a hypoglycemic agent. METHODS Double-blind phase I clinical trial was conducted at the general hospital and a private hospital in Matara in August 2009. All the participants were given a common meal for dinne...
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ژورنال
عنوان ژورنال: journal of applied pharmaceutical science
سال: 2022
ISSN: ['2231-3354']
DOI: https://doi.org/10.7324/japs.2021.120103