Antidepressant-Like Effect of Endomorphin-1 and Endomorphin-2 in Mice
نویسندگان
چکیده
منابع مشابه
D-Pro-Endomorphin-1 and D-Pro-Endomorphin-2, Respectively, Attenuate the Antinociception Induced by Endomorphin-1 and Endomorphin-2 Given Intrathecally in the Mouse
First, the antinociception with the tail-flick test of D-Pro-endomorphin-1 and D-Pro-endomorphin-2 given i.t. was compared with that produced by endomorphin-1 and -2 in male CD-1 mice. High doses of D-Pro-endomorphin-1 (0.2–0.4 pmol) and D-Pro-endomorphin-2 (300–800 pmol) given i.t. produced antinociception with low intrinsic activity [about 25% maximum possible effect (MPE)] compared with that...
متن کاملPharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain.
The recently isolated peptides endomorphin-1 and endomorphin-2 have been suggested to be the endogenous ligands for the mu receptor. In traditional opioid receptor binding assays in mouse brain homogenates, both endomorphin-1 and endomorphin-2 competed both mu1 and mu2 receptor sites quite potently. Neither compound had appreciable affinity for either delta or kappa1 receptors, confirming an ea...
متن کاملOpposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice
Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system on the supraspinal antinociceptive effects induced by the endogenous µ-opioid receptor agonists, endomorphin-1 (EM-1) and endomorphin-2 (EM-2)...
متن کاملDifferential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.
Two highly selective mu-opioid receptor agonists, endomorphin-1 and endomorphin-2, have been identified and postulated to be endogenous mu-opioid receptor ligands. We determined the antinociceptive effects of these two ligands at the supraspinal level in mice with the tail-flick and hot-plate responses. The i.c.v. injection of endomorphin-1 and -2 inhibited the tail-flick and hot-plate response...
متن کاملDifferential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse.
We have previously demonstrated that the antinociception induced by either endomorphin-1 or endomorphin-2 given supraspinally is mediated by the stimulation of mu-opioid receptors. However, the antinociception induced by endomorphin-2 given supraspinally contains additional components, which are mediated by the spinal release of dynorphin A (1-17) acting on kappa-opioid receptors and the spinal...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2006
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1301149