منابع مشابه
Insulin-mimetic action of vanadate: role of intracellular magnesium.
The insulin-mimetic effect of vanadate is well established, and vanadate has been shown to improve insulin sensitivity in diabetic rats and humans. Although the exact mechanism(s) remain undefined, we have previously demonstrated a direct relation of intracellular free magnesium (Mg(i)) levels to glucose disposal, to insulinemic responses following glucose loading, and to insulin-induced ionic ...
متن کاملVasoflux, a new anticoagulant with a novel mechanism of action.
BACKGROUND Heparin and direct thrombin inhibitors, such as hirudin, have limitations in the treatment of acute coronary syndromes. Heparin does not inactivate fibrin-bound thrombin, whereas hirudin fails to block thrombin generation. In contrast, Vasoflux is a novel anticoagulant that inactivates fibrin-bound thrombin and attenuates factor Xa generation. METHODS AND RESULTS Vasoflux is prepar...
متن کاملSome factors influencing the anticoagulant action of heparin.
IT has been generally assumed that the anticoagulant action of heparin is due to direct combination with prothrombin, thrombin, or kinase. The chief experimental facts on this point have been confirmed by Mustard & Jaques [1937] and may be summarized as follows. When citrated plasma and thrombin are used to test the action of heparin, the heparin acts as an antithrombin [Howell, 1925]. When kin...
متن کاملEffect of sodium vanadate
Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, AGEPC) and sodium vanadate (a phosphotyrosine phosphatase inhibitor) induced a timeand concentration-dependent increase in phosphotyrosine in several proteins and stimulated prostaglandin (PG) E2 production in cultured rat Kupffer cells. In addition, vanadate induced a decrease in the surface expression of AGEPC recepto...
متن کاملMechanism of inhibition of glycolysis by vanadate.
Vanadate is known to inhibit several phosphatases including Na+, K+-ATPase, alkaline phosphatase, and glyceraldehyde-3-P dehydrogenase. Inhibition presumably results because vanadium adopts a stable structure which resembles the transition state of phosphate during the reactions involving these enzymes. We performed experiments to further examine the effects of vanadate (VO3-4) on erythrocyte (...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1992
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.40.174