Anticancer effect of ursolic acid via mitochondria‑dependent pathways (Review)
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چکیده
منابع مشابه
The effects of ursolic acid on cytokine production via the MAPK pathways in leukemic T-cells
Ursolic acid (UA) is a pentacyclic triterpenoid carboxylic acid that is found in plants and herbal products. It is one of the chemopreventive agents, which can suppress cancer cell proliferation and induce apoptosis. UA possesses various biological activities including anticancer, anti-inflammatory, anti-oxidative and hepatoprotective activity. We investigated the effect of UA on cytokine produ...
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Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeutic compounds. In the present study, the therapeutic potential and toxicity of ursolic acid (UA), isolated from the leaves of Baccharis uncinella C. DC. (Aste...
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Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human li...
متن کاملDetermination of Ursolic Acid and Ursolic Acid Lactone in the Leaves of Eucalyptus tereticornis by HPLC
Um método simples, isocrático, de HPLC foi desenvolvido para quantificação simultânea de dois triterpenos bioativos, ácido ursólico e lactona do ácido ursólico em folhas de E. tereticornis. As amostras foram analisadas em coluna RP-18 (4,6 × 250 mm, 5 μm) com metanol e água acidificada a pH 3,5 com TFA (88:12) a 210 nm. O método foi validado e aplicado para a quantificação simultânea dos triter...
متن کاملUrsolic Acid and Other Pentacyclic Triterpenoids: Anticancer Activities and Occurrence in Berries
Ursolic acid and related pentacyclic triterpenoids have been isolated and identified as constituents of various berries, particularly cranberries (Vaccinium macrocarpon) and other Vaccinium species. In vitro studies have shown that these compounds possess anti-inflammatory and anti-cancer activities. These compounds reportedly inhibit the growth of numerous tumor cell lines including colon, bre...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2019
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2019.10171