Antibody response after hepatitis B vaccine boost mapped with peptide-phage display

can Isolated hepatitis B core antibody in HIV-infected patients response to hepatitis B vaccine help to elucidate the cause?

Probing antinuclear antibody specificities by peptide phage display libraries.

OBJECTIVE To uncover the specificities of autoantibodies to nuclear proteins (ANA) in patients with juvenile rheumatoid arthritis (JRA). METHODS Peptide ligands for ANA were selected by panning random peptide phage display libraries on antibodies binding to HEp-2 cells. Positive phage clones were identified by the immunoscreening technique. RESULTS Groups of peptides were identified, some o...

significance of response to hepatitis b recombinant vaccine in subjects with isolated antibody to hepatitis b core antigen

background it is important to differentiate whether isolated anti-hbc is due to false positive results or the prior exposure to hepatitis b virus, because individuals with false-positive anti-hbc can benefit from vaccination and their blood can be safely transfused. to distinguish between these two conditions, we evaluated the serologic response to hepatitis b vaccine. methods ninety subjects w...

Significance of Response to Hepatitis B Recombinant Vaccine in Subjects with Isolated Antibody to Hepatitis B Core Antigen

BACKGROUND It is important to differentiate whether isolated anti-HBc is due to false positive results or the prior exposure to hepatitis B virus, because individuals with false-positive anti-HBc can benefit from vaccination and their blood can be safely transfused. To distinguish between these two conditions, we evaluated the serologic response to hepatitis B vaccine. METHODS Ninety subjects w...

Antibody response to melanoma helper-peptide vaccine correlates with survival

Introduction/Background A melanoma vaccine comprising 6 peptides presented by Class II MHC molecules was safe and induced CD4+ T cell responses in 81% of recipients. Circulating CD4+ T cell responses to these 6 melanoma helper peptides (6MHP) have been associated with patient survival. We hypothesized that these intermediate length peptides (14-23 amino acids) may also induce antibody responses...