Antibody-mediated marrow failure after allogeneic bone marrow transplantation

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Antibody-mediated marrow failure after allogeneic bone marrow transplantation.

Marrow graft failure observed in association with histocompatibility differences between donor and recipient is often attributed to rejection mediated by host-derived cytolytic T lymphocytes. The data presented in this report indicate that persistent host antibodies specific for donor antigen may also mediate graft failure, either by antibody-dependent cell-mediated cytotoxicity (ADCC), or comp...

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Allogeneic Bone Marrow Transplantation

A 1 3-yr-old male with acute myelogenous therapy. Then, 53 yr later, he developed leukemia was treated with various chemoan extramedullary relapse with a chlotherapy regimens for 3 yr and then underroma of his maxillary sinus. This case ilwent an allogeneic bone marrow translustrates the need for prolonged followup plantation. The donor marrow was sucof transplant recipients and suggests that c...

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Immune-mediated optic neuritis after unrelated allogeneic bone marrow transplantation.

There have been few reports on immune-mediated neurological disturbances and none on solitary occurrence of optic neuritis after bone marrow transplantation (BMT). We experienced a very rare case of immune-mediated optic neuritis as one symptom of graft-versus-host disease (GVHD). A 34-year-old man with chronic myelogenous leukemia in accelerated phase received BMT from a human leukocyte antige...

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Generalized vitiligo after allogeneic bone marrow transplantation.

Sir, Vitiligo is a common, depigmenting disorder characterized by well-circumscribed cutaneous macules devoid of melanocytes on the epidermis. Bone marrow transplantation (BMT), which has significant therapeutic benefits in haematologic disorders, such as leukaemia and aplastic anaemia, provides convincing evidence for the role of the immune system in some autoimmune diseases (1). In this repor...

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ژورنال

عنوان ژورنال: Blood

سال: 1989

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v74.5.1477.1477