Antibody diversity: New mechanism revealed

Molecular Mechanism and Energy Basis of Conformational Diversity of Antibody SPE7 Revealed by Molecular Dynamics Simulation and Principal Component Analysis

More and more researchers are interested in and focused on how a limited repertoire of antibodies can bind and correspondingly protect against an almost limitless diversity of invading antigens. In this work, a series of 200-ns molecular dynamics (MD) simulations followed by principal component (PC) analysis and free energy calculations were performed to probe potential mechanism of conformatio...

Genetic diversity of Iranian melon cultigens revealed by AFLP markers

Iran is a part of the secondary centre of origin of melons, and therefore, there is a wealth of genetic variation of these species in this country. The Amplified Fragment Length Polymorphism (AFLP) marker was applied to investigate the genetic variations among five major Iranian melon cultigens (Cucumis melo) and ‘Ananasi’ as a general well-known cultivar. Ten primer pairs were used on 90 indiv...

Mechanism of antibody diversity: germ line basis for variability.

1. S. P. 6 Ri6rdfiin and G. Daniel, New Grange (Praeger, New York, 1964). 2. G. Hawkins, Stonehenge Decoded (Doubleday, Garden City, N.Y., 1965). 3. A. Thom, Megalithic Sites in Britain (Oxford, London, 1967). 4. G. Daniel, The Megalithic Builders of Western Europe (Hutchenson, London, 1959), pp. 111-113. 5. Actually this tumulus represents what Thom calls a type D ring, one in which the two pi...

Molecular Switch Mechanism Revealed

Cuprate Liquid Crystal Recent experimental work has revealed exotic electronically ordered phases in correlated electron systems akin to those seen in conventional liquid crystals. These effects have manifested themselves as anisotropic transport properties, in which conductivity depends upon direction within the sample. Hinkov et al. (p. 597, published online 10 January) used neutron scatterin...

Display Library Repertoire as Revealed from a Bacteriophage Analysis of the Diversity of a Sheep Antibody