Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy Patients and Controls
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چکیده
منابع مشابه
ImmunogenIcity of thE PandemRIX A (H1N1) 2009 Influenza vaccine in hemodialysed and renal transplanted patients
Introduction Swine-origin pandemic human influenza A(H1N1)2009 rapidly spread around the world since its initial reporting on the 25th of April 2009. To counter the virus, different vaccines were developed. In Belgium, the Pandemrix vaccine of GSK was used. Part of the Belgian population was vaccinated, especially those belonging to risk groups (immunodepressed patients, healthcare providers, p...
متن کاملNo Serological Evidence of Influenza A H1N1pdm09 Virus Infection as a Contributing Factor in Childhood Narcolepsy after Pandemrix Vaccination Campaign in Finland
BACKGROUND Narcolepsy cataplexy syndrome, characterised by excessive daytime sleepiness and cataplexy, is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02. A sudden increase in the incidence of childhood narcolepsy was observed after vaccination with AS03-adjuvanted Pandemrix influenza vaccine in Finland at the beginning of 2010. Here, we analysed whether the ...
متن کاملAutoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus.
Following the mass vaccinations against pandemic influenza A/H1N1 virus in 2009, a sudden increase in juvenile onset narcolepsy with cataplexy (NC) was detected in several European countries where AS03-adjuvanted Pandemrix vaccine had been used. NC is a chronic neurological disorder characterized by excessive daytime sleepiness and cataplexy. In human NC, the hypocretin-producing neurons in the...
متن کاملAntigenic Differences between AS03 Adjuvanted Influenza A (H1N1) Pandemic Vaccines: Implications for Pandemrix-Associated Narcolepsy Risk
BACKGROUND Narcolepsy results from immune-mediated destruction of hypocretin secreting neurons in hypothalamus, however the triggers and disease mechanisms are poorly understood. Vaccine-attributable risk of narcolepsy reported so far with the AS03 adjuvanted H1N1 vaccination Pandemrix has been manifold compared to the AS03 adjuvanted Arepanrix, which contained differently produced H1N1 viral a...
متن کاملPredicting AH1N1 2009 influenza epidemic in Southeast Europe
AIM To use the data on the AH1N1 2009 influenza epidemic in the Southern hemisphere countries to predict the course and size of the upcoming influenza epidemic in South-Eastern Europe (SEE) countries and other regions of the World with temperate climate. METHOD We used a comparative epidemiological method to evaluate accessible electronic data on laboratory-confirmed deaths from AH1N1 2009 in...
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ژورنال
عنوان ژورنال: Viral Immunology
سال: 2017
ISSN: 0882-8245,1557-8976
DOI: 10.1089/vim.2017.0066