Antibodies to Streptococcal Surface Enolase React with Human α‐Enolase: Implications in Poststreptococcal Sequelae
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چکیده
منابع مشابه
Defining the structural basis of human plasminogen binding by streptococcal surface enolase.
The flesh-eating bacterium group A Streptococcus (GAS) binds and activates human plasminogen, promoting invasive disease. Streptococcal surface enolase (SEN), a glycolytic pathway enzyme, is an identified plasminogen receptor of GAS. Here we used mass spectrometry (MS) to confirm that GAS SEN is octameric, thereby validating in silico modeling based on the crystal structure of Streptococcus pne...
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Covalent linkage of a bacterial polysaccharide to a protein greatly enhances the carbohydrate's immunogenicity and its binding to solid surfaces in immunoassays. These findings have spurred the development of glycoconjugate vaccines to prevent serious bacterial infections as well as the use of glycoconjugates as coating antigens in bioassays. We evaluated sera from women immunized with unconjug...
متن کاملMonoclonal antibodies specific for platelet glycoproteins react with human monocytes.
Three monoclonal antibodies, P256 , P140, and P112 , react with the 135,000 mol wt IIb component of the glycoprotein IIb/IIa complex. They also react with a 200,000-mol wt protein present at low levels in the complex. Using immunofluorescence techniques, monoclonal antibodies P140 and P112 , but not P256 , can be shown to bind to 80% of human monocytes. However, P256 was able to immunoprecipita...
متن کاملResponse to comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2".
Vassalli et al.'s study does not involve or provide additional data regarding influenza virus, influenza vaccines, human samples, animal models of narcolepsy, or experiments related to mimicry and cross-reactivity. They present data on the distribution of hypocretin (HCRT) (also known as orexin) receptors in the brain of an engineered mouse developed by them.
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2000
ISSN: 0022-1899,1537-6613
DOI: 10.1086/317604