Antibodies against neo-epitope tTg complexed to gliadin are different and more reliable then anti-tTg for the diagnosis of pediatric celiac disease
نویسندگان
چکیده
منابع مشابه
Antibodies against deamidated gliadin peptides and tissue transglutaminase for diagnosis of pediatric celiac disease.
OBJECTIVES The aim of the present study was to evaluate diagnostic performance and actual costs in clinical practice of immumoglobulin (Ig)G/IgA deamidated gliadin peptide antibodies (DGP) as a complement to IgA antibodies against tissue transglutaminase (tTG) for the diagnosis of pediatric celiac disease (CD). METHODS All of the consecutive patients younger than 18 years tested for tTG and/o...
متن کاملDEVELOPMENT OF DIAGNOSTIC AMPEROMETRIC AND PIEZOELECTRIC IMMUNOSENSORS BASED ON HUMAN OPEN-tTG FOR RECOGNITION OF ANTI-tTG ANTIBODIES IN CELIAC DISEASE
Sviluppo di immunosensori amperometrici e piezoeletrici per la rivelazione di anticorpi anti-tTG nella diagnosi della malattia celiaca Il presente lavoro riguarda la realizzazione di immunosensori a trasduzione amperometrica e piezoelettrica, basati sull’immobilizzazione della transglutaminasi tissutale in forma aperta (Open-tTG). Entrambe le strategie hanno permesso di ottenere un modello affi...
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1. Biller BM, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, et al. Treatment of adrenocorticotropin-dependent Cushing’s syndrome: a consensus statement. J Clin Endocrinol Metab 2008;93:2454–62. 2. Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK. Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration: a new test to distinguish Cushing’s syndro...
متن کاملThe Diagnostic Value of Serum IgG-Antigliadin, IgA Anti-endomysial and IgA Anti-tissue Transglutaminase Antibodies for Pediatric Celiac Disease
Background and Objective: Celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. In this study we considered and compared sensitivity and specificity of serological tests in patients with celiac disease. Materials and Methods: In this cross-sectional study we prospectively recruited children with suspected c...
متن کاملAntibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children.
BACKGROUND AGA IgA II and AGA IgG II have recently been suggested as reliable tools for celiac disease (CD) diagnosis. We compared their utility for diagnosis and monitoring CD in children with that of tTG IgA, an established CD marker. METHODS We studied a cohort of 161 CD and 129 control children in whom CD was histologically confirmed or ruled out. We followed 37 children with CD on a glut...
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ژورنال
عنوان ژورنال: Journal of Immunological Methods
سال: 2016
ISSN: 0022-1759
DOI: 10.1016/j.jim.2015.12.006